, Kraag GR PGA is a simple instrument and the result is easily understood. Unauthorized use of these marks is strictly prohibited. , Stavrakis S BILAGAB . Kiani AN Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) - Full A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). Mina R A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. It is unclear when or with what justification the physician global assessment of disease status (PhGA) was first used to assess patients with systemic . , Mina R , Andreoli L , Mosca M Intoduction to X 20 - Physician Global Assessment Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. , Beresford MW et al. physician global assessment (pga) - Assesschild Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv , Rairie JE Learn more. Please check for further notifications by email. Oxford University Press is a department of the University of Oxford. Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. Responsiveness. , Kalunian K Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Instrument selection using the OMERACT filter 2.1: the OMERACT methodology, The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes, Health measurement scales: a practical guide to their development and use, A decrease in complement is associated with increased renal and hematologic activity in patients with systemic lupus erythematosus, Efficacy and safety of methotrexate in articular and cutaneous manifestations of systemic lupus erythematosus, Performance of SLEDAI-2K to detect a clinically meaningful change in SLE disease activity: a 36-month prospective cohort study of 334 patients, Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort, Comparison of the systemic lupus erythematosus activity questionnaire and the systemic lupus erythematosus disease activity index in a black Barbadian population, A pilot study to determine the optimal timing of the Physician Global Assessment (PGA) in patients with systemic lupus erythematosus, Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments, Derivation and validation of the SLE Disease Activity Score (SLE-DAS): a new SLE continuous measure with high sensitivity for changes in disease activity, Clinical SLEDAI-2K zero may be a pragmatic outcome measure in SLE studies, Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE, Validation of SIMPLE index for lupus disease activity, Performance characteristics of different anti-double-stranded DNA antibody assays in the monitoring of systemic lupus erythematosus, Psychometric properties of MDHAQ/RAPID3 in patients with systemic lupus erythematosus, Therapeutic adherence in patients with systemic lupus erythematosus: a cross-sectional study, Sensitivity analyses of four systemic lupus erythematosus disease activity indices in predicting the treatment changes in consecutive visits: a longitudinal study, Comparison of the lupus foundation of America-rapid evaluation of activity in lupus to more complex disease activity instruments as evaluated by clinical investigators or real-world clinicians, Lupus low disease activity state is associated with a decrease in damage progression in Caucasian patients with SLE, but overlaps with remission, Impact of disease activity on health-related quality of life in systemic lupus erythematosusa cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS), Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study, Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus, Cross-cultural validation of Lupus Impact Tracker in five European clinical practice settings, Failure of a systemic lupus erythematosus response index developed from clinical trial data: lessons examined and learned, Belimumab for the treatment of recalcitrant cutaneous lupus, Progression of noncalcified and calcified coronary plaque by CT angiography in SLE, Impact of heart rate variability, a marker for cardiac health, on lupus disease activity, The lupus impact tracker is responsive to changes in clinical activity measured by the systemic lupus erythematosus responder index, Validation of the Lupus Impact Tracker in an Australian patient cohort, Axl, ferritin, IGFBP2 and TNFR2 as biomarkers in systemic lupus erythematosus, Lupus anticoagulant, disease activity and low complement in the first trimester are predictive of pregnancy loss, Lupus Impact Tracker is responsive to physician and patient assessed changes in systemic lupus erythematosus, Predictors of pregnancy outcomes in patients with lupus: a cohort study, Clinical, laboratory and health-related quality of life correlates of Systemic Lupus Erythematosus Responder Index response: a post hoc analysis of the phase 3 belimumab trials, Validation of the LupusPRO in Chinese patients from Hong Kong with systemic lupus erythematosus, The Swiss Systemic lupus erythematosus Cohort Study (SSCS)cross-sectional analysis of clinical characteristics and treatments across different medical disciplines in Switzerland, How should lupus flares be measured? Epub 2014 Apr 11. Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. In an epratuzumab trial, the absence of deterioration of the PGA (not >10% worsening) was one of the items to achieve a BILAG-based Composite Lupus Assessment (BICLA) response [105]. , Socher SA Your comment will be reviewed and published at the journal's discretion. The Author(s) 2020. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Flower C We have systematically reviewed all studies about validation of the PGA in SLE. , Alarcn GS , Wallace DJ The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. et al. Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. and transmitted securely. , Petri M. Foering K Moher D Brunner HI However, the PGA allows for the measurement of disease activity in a global way (content validity). , Emamikia S , Magder L , Karp DR This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. AU - Kasitanon, Nuntana. , Ibaez D , Bouter LM The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). Exagen Diagnostics Inc (XGN) - Product Pipeline Analysis, 2022 Update Genetic linkage has related dysfunction of . PGA0.3. , Lin M , Urowitz MB What Does It Mean to Be a British Isles Lupus Assessment Group-Based Oxford Textbook of Neuropsychiatry - 2020 | PDF | Psychiatry PGA - Lupus Research Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. , Gladman DD physician global assessment Latest Research Papers | ScienceGate This important heterogeneity in the anchoring of the PGA prevented us from performing a meta-analysis of reliability data. FOIA Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. Bethesda, MD 20894, Web Policies , Koutsoviti S , Ibanez D et al. A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. In the second column, the definitions were reported according to the VAS used in the study. Ahmed S. - Managing Director/ Medical Lead - Global Bio-pharma et al. Cloud, mobility, security, and more. Conclusion: Ann Rheum Dis 2011;70:54-9. et al. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. Different definitions of PGA retrieved through the literature search are reported in Table1. , Block JA This concept includes content validity, face validity, construct validity and criterion validity. Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. Gordon C To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). , Nelson S PGA-IGA described in ePROVIDE - Mapi Research Trust , McGuire JL. Liang MH , Wallace DJ Tyk2 Targeting in Immune-Mediated Inflammatory Diseases 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. How should lupus flares be measured? In our centre, new tools for the assessment of SLE activity: the Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST) were developed and validated.
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